产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    主要用于肿瘤方面的研究：C-kit是原癌基因的蛋白产物，为III型跨膜蛋白酪氨酸激酶生长因子受体蛋白。80-100%胃间质肉瘤(GIST)CD117+,可与CD34联合应用。
    CD117还可以用于鉴别淋巴瘤中肥大细胞发生的肿瘤，和作为部分睾丸生殖细胞瘤的标记物。
    近年研究，CD117作为胃间质肉瘤(GIST)免疫组化检查特异性标记物，可用于临床指导GIST个性化的靶点药物治疗。
    c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.
    mol wt:145kDa

    Also known as:
    C Kit; CD 117; CD117; CD117 antigen; KIT; Mast/stem cell growth factor receptor; PBT; Proto oncogene tyrosine protein kinase Kit; SCF Receptor; SCFR; Stem cell factor receptor; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog