产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 (石蜡切片需做抗原修复)
产品介绍
DNA甲基转移酶-1在多种肿瘤细胞中表达量相当高,而在正常成人细胞中则低表达,因此dnmt1基因的高表达与肿瘤的发生有密切的关系。 dnmt-1 对细胞周期、增殖及凋亡有一定的的影响。细胞核表达 (isoform CRA_a)为抑制细胞增殖、促进细胞凋亡,为肿瘤的基因治疗提供依据。 有研究认为:Dnmt1蛋白过表达在人胃癌的发生和发展中起一定作用。
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Alternate Names: DNMT1; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; MCMT; M.HsaI; CXXC-type zinc finger protein 9; Dnmt1; FLJ16293; AIM; DNMT; CXXC9; M.HsaI; DNA; MCMT; MGC104992; EC 2.1.1.37
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