产品类别

 兔抗人、大、小鼠Galectin-3抗体

产品价格

 0.2ml/890元  

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

 Galectin-3是Galectin（半乳凝素）家族的一员，能识别糖蛋白和糖脂的特异性低聚糖结构，参与多种生理和病理过程，包括细胞生长和凋亡、细胞黏附、新生血管形成和肿瘤浸润与转移等。Galectin-3在肿瘤的发生、发展及转移中起重要作用。
 Galectin-3在某些肿瘤组织中高表达，其在不同类型肿瘤，如结直肠癌、胃癌、胰腺癌、甲状腺癌及肺癌等患者中的高表达水平，与低生存、肿瘤复发、预后差及对化疗药物敏感性降低相关对于某些肿瘤，Galectin-3有可能成为一个有价值的诊断标志和治疗靶点。
 Galectin-3 is a member of the Galectin family. It recognizes specific oligosaccharide structures on glycoproteins and glycolipids and is involved in various biological phenomena including cell growth, apoptosis, adhesion and angiogenesis. Galectin-3 plays an important role ii carcinoma development, aggressiveness and metastasis. Galectin-3 is overexpressed in certain neoplasms and its high expression levels are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy in patients with different types of malignancy, such as colorectal cancer, gastric cancer, pancreatic cancer, thyroid cancer and lung cancer. In certain neoplasms, Galectin-3 may be a valuable diagnostic marker and target of malignancy treatment.
 Also known as:
 Galactose-specific lectin 3; Mac-2 antigen;IgE-binding protein; 35 kDa lectin; Carbohydrate-binding protein 35;CBP 35; Laminin-binding protein; Lectin L-29; L-31;Galactoside-binding protein; GALBP