产品类别

 兔抗人、大、小鼠细胞表面趋化因子受体3抗体

产品价格

 0.2ml/650元  

产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

 WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

 

产品介绍

 G蛋白偶联受体CKR-L2（ G protein-coupled receptor-2 ）又称：又称G蛋白偶联受体9(GPR9)-是受体中最大的家族，大多数的细胞膜表面受体都是G蛋白偶联受体家族的成员。
 G蛋白偶联受体是药物研发中最广泛应用的成功药靶，作用于G蛋白偶联受体的药物对疼痛、认知障碍、高血压、胃溃疡、鼻炎和哮喘等各类疾病具有良好的治疗作用。G-蛋白受体在目前临床上使用的约500种药物中，有30%以上以调节G蛋白偶联受体功能为靶标。
CXC-R3
CXCR-3
Interferon-inducible protein 10 receptor
IP-10 receptor
CKR-L2
CD183 antigen
G protein-coupled receptor 9
C-X-C Chemokine receptor
 Summary: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed IP10(interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to this protein. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization(phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. This gene is prominently expressed in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that this gene and its chemokines participate in the recruitment of inflammatory cells. Therefore, this protein is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. Multiple transcript variants encoding different isoforms have been found for this gene.