产品介绍

    An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
    Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.
    mol wt:72kDa
    Other Aliases:
    ABC15; ABCG 2; ABCG2; ABCP; ATP-binding cassette sub-family G member 2; BCRP1; BMDP; Breast cancer resistance protein; CDw338; CDw338 antigen; EST157481; MGC102821; Mitoxantrone resistance associated protein; MRX; MXR; MXR1; Placenta-specific ATP-binding cassette transporter