产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
转录调节因子（Transcriptin Regulators）
STAT-信号转导和转录激活因子蛋白家族是近年来发现的一类转录因子.通过JAK-STAT途径介导许多由细胞因子诱导的反应,参与细胞的信号转导和转录。
STATs are Signal Transducers and Activators of Transcription. STATs were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6).
STATs are a family of cytoplasmic proteins that participate in cellular responses to cytokines and growth factors. STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Many cytokines involved in immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases. Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID and leukemia, and programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity and cell growth regulation. STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL12 and IL4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland. STAT1/STAT2 form a heterodimer which, in association with a DNA-binding adapter protein, p48/IFN regulatory factor 9 (IRF9), is part of the ISGF3 transcription factor complex.
Specific functions of the various members of the STAT family are poorly understood. STAT1 and STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer. The unique acidic domain of the carboxy-terminal region of STAT2 may interact with cAMP-response-element binding protein. STAT2 has been shown to be activated by IFNalpha/beta and associate with the transcription factors p48, and P300.
mol wt:93kDa(human, rat); 101kDa(mo)
Other Aliases:
signal transducers and activators of transduction2; 1600010G07Rik; AW496480; Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator; ISGF3; MGC59816; P113; signal transducer and activator of transcription 2 113kD; STAT113
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