产品介绍

   神经生物学相关蛋白（Neurobiology）
  
   SNCG（gamma-Synuclein）蛋白在各种癌症组织中呈广范表达，存在较高的异常表达率，SNCG蛋白表达与癌症分期有关，I期表达率低，Ⅱ～Ⅳ期表达率高。尤其重要的是：经研究发现无论何种原发性肿瘤，SNCG蛋白的出现与癌症远处转移都有很高的关联性。

    The synculein family consists of 3 highly conserved proteins of between 120 and 140 amino acids that share substantial sequence homology. Each has a series of loosely repeated motifs throughout the first 93 amino acids and an acid region toward the C terminal. The proteins are heat stable and relatively soluble. Three synucleins have been identified and termed alpha, beta and gamma synuclein and are located in the neuronal cytosol and enriched in presynaptic terminals,gamma synuclein is also expressed in many other non-neuronal tissues. Although the precise function of the synucleins are unknown a role in membrane plasticity has been suggested. The synucleins have been implicated in a number of diseases. It has been reported that in breast cancer increased expression of gamma synuclein correlates with disease progression.
    mol wt:13.5kDa
    Other Aliases:
    BCSG1; Breast cancer specific gene 1 protein; Breast cancer specific protein 1; Breast cancer-specific gene 1 protein; Gamma synuclein; Persyn; PRSN; SNCG; SR; Synoretin; Synuclein gamma