产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

    基质细胞衍生因子－1(SDF-1)又称趋化因子CXCL12 是小分子的细胞因子，属于趋化因子蛋白家族。它有两种形式, SDF-1α/CXCL12a和SDF-1β/CXCL12b。趋化因子有四个保守的半胱氨酸残基形成两对双硫键以构成趋化因子的特殊结构。第一第二半胱氨酸残基之间隔着一个介入氨基酸残基。
基质细胞源性生长因子1:趋化因子CXCL12对淋巴细胞有强烈的趋化作用并在发育中起重要作用。在胚胎发育中CXCL12引导造血干细胞从胎儿肝脏到骨髓的迁徙。 CXCL12可以在许多组织(包括脑,胸腺,心,肺,肝,肾,骨髓,脾脏)中表达。
趋化因子CXCL12的受体是CXCR4。但是,最近有人认为CXCL12还可以与CXCR7受体结合。

    The cell source growth factor 1: tend to turn the factor CXCL12 to have tend of mightiness to the lymphoid cell to turn the function and rise the important function in the growth.The CXCL12 leading builds the blood stem cell in embryo develop from embryo's liver to the change residence of marrow. CXCL12 can expression in many tissues ( include the brain, thymus gland, heart, lung, liver, kidney, marrow, spleen). Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses.
    mol wt:9.8kDa
    Other Aliases:
    Sdf1; stromal cell derived factor-1; Chemokine (C X C motif) ligand 12; CXCL12; hIRH; PBSF; Pre B cell growth stimulating factor; SCYB12; SDF 1 alpha; SDF 1; SDF 1 beta; SDF 1b; SDF1; SDF1a; SDF1b; Stromal cell derived factor 1; TLSF a; TLSF b; TLSFa; TLSFb; TPAR1