产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

PTEN是一种肿瘤抑制基因（N端抗体），在维持细胞的增殖、分化和凋亡平衡起重要作用，该基因在许多肿瘤常表现为突变或杂合性丢失，NMAC1主要用于胶质瘤、乳腺、前列腺癌、非何杰金氏淋巴瘤各种恶性肿瘤的研究.分子量：44KDa
Potential tumor suppressor. Acts as a phosphoinositide3-phosphatase by regulating PtdIns (3,4,5)P3 levels. Involved in regulation of the AKT1 signaling pathway. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers with the variety to suffer from the comprehensive disease easilyrelevant.The activity that passes to repress the Akt regulates the cell period, the cell ground rule decease and glues to connect.This text discussed PTEN structure, function and its correlationses, the PTEN is in tumor repress function mechanism
Also known as:
• Bannayan Zonana syndrome • BZS a • ITGA 2 • MGC11227 • MHAM • MMAC 1 • MMAC1 • Multiple hamartoma (Cowden syndrome) • Mutated in Mutiple Advanced Cancers 1 • Phosphatase and Tensin Homolog • Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN • Phosphatidylinositol 345 trisphosphate 3 phosphatase • Platelet antigen BR • PTEN 1 • PTEN1 • Tensin homolog • TEP 1 • TEP1 • VLA 2 Receptor Alpha Subunit