产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
产品介绍
激酶和磷酸酶（Kinases and Phosphatases）
MAPK14
mitogen-activated protein kinase 14
non-phospha
丝裂原活化蛋白激酶p38(p38 MAPK、非磷酸化)参与细胞生长、增殖、分化、死亡及细胞间的功能同步等多种生理过程.
p38MAPK是丝裂原活化蛋白激酶家族中的成员之一，大量研究显示p38在能量代谢中具有广泛的作用。p38参与脂肪组织、骨骼肌、胰岛细胞和肝脏等组织、器官的能量代谢.分子量：38KDa
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Also known as:
CSAID Binding Protein 1 CSAID binding protein CSBP 1 CSBP 2 CSBP CSBP1 CSBP2 Cytokine suppressive anti inflammatory drug binding protein EXIP MAP kinase MXI2 MAP kinase p38 alpha MAPK 14 MAPK14 MAX interacting protein 2 Mitogen Activated Protein Kinase 14 Mitogen activated protein kinase p38 alpha Mxi 2 Mxi2 p38 ALPHA p38 MAPK p38ALPHA PRKM14 PRKM15 RK SAPK 2A SAPK2A Stress Activated Protein Kinase 2A
|
