产品标准

 浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500    （石蜡切片需做抗原修复）

产品介绍

   支架蛋白IQGAP1与许多重要的细胞活动紧密相关，如黏附和迁移。研究发现在损伤修复、组织发展、肿瘤转移等过程中，IQGAP1的表达和功能有明显改变。同时作为Rh.GTPase信号的主要效应因子，IQGAP1能传递细胞外信号至黏附素复合体、细胞骨架以及细胞核。通过上述信号通路，IQ-GAP1协助细胞完成一系列重要生理病理活动.

    IQGAP1 is a widely expressed protein than interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology. It binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
    mol wt:182kDa
    Other Aliases:
    IQ motif containing GTPase activating protein 1; KIAA0051; p195; Ras GTPase activating like protein 1